Scientist

Salary:

Our research team in Los Angeles is seeking a highly motivated individual to play a critical role in viral vector discovery and process development. Primarily, the role will execute viral vector production, purification, process characterization, production scale-up, and analytical testing. At the same time, your responsibilities and priorities are expected to evolve, so adaptability is a must. Execution of accurate, up-to-date records of experiments and prompt reporting of results will be required. Individuals must be proactive self-starters who adapt to both independent and team-based tasks. This position is laboratory-based with the possibility of direct reports.

To Apply:
TCRCure Biopharma provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state, and local laws. TCRCure Biopharma complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

If you are interested in applying for this opportunity, please submit your resume and cover letter. All submissions will be evaluated, and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.

Qualifications and Skills:
Ph.D. with experience in immunology, molecular biology, or a related field
Demonstrated expertise in molecular biology, cloning, PCR, and genetic manipulation
Proficiency with mammalian cell transfection/transduction, and viral vector packaging.
Experience with flow cytometers, bioreactors, FPLC, TFF systems.
Hands-on experience with stable cell lines development for retro or lentiviral vectors is preferred.
Hands-on experience with T cell or other primary leukocyte culture. Previous experience with CAR-T or immunotherapy is preferred.
Strong record-keeping skills and attentional to detail in documentation
Excellent communication and interpersonal skills for working closely with a diverse array of team members

Sr. Research Associate

Salary:

Our research team in Los Angeles is seeking a highly motivated individual to perform hands-on laboratory work. The role will have rapidly evolving priorities and ever-changing workloads, so adaptability is a must. We value teamwork and collaboration, and effectively working with scientists and other associates in the group to help our product development succeed is expected. Responsibilities include but are not limited to designing and developing strategies for novel T cell therapies; planning, and executing in vitro functional assays with human T cells or NK cells; working cross-functionally with the in vivo development team to validate novel products; performing molecular biology experiments such as PCR, cloning, DNA preparations, etc.

To Apply:
TCRCure Biopharma provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state, and local laws. TCRCure Biopharma complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

If you are interested in applying for this opportunity, please submit your resume and cover letter. All submissions will be evaluated, and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.

Qualifications and Skills:
B.S or M.S. (M.S. preferred) in Biological Sciences or a related scientific discipline
3+ years of industry experience
Working knowledge and broad understanding of immunology and adoptive cell therapy
Hands-on experience with T cell, NK cell, or other primary leukocyte culture. Previous experience with CAR-T or immunotherapy is preferred
Proficiency with mammalian cell transfection/transduction, preferably with viral vectors
Experience with multiparametric flow cytometry is strongly preferred
Demonstrated expertise in molecular biology, cloning, PCR, and genetic manipulation is preferred
Strong record-keeping skills and attentional to detail in documentation
Basic understanding of GLP, GDP and GMP requirements
Excellent communication and interpersonal skills for working closely with a diverse array of team members
Comfortable and efficient in a fast-paced, dynamic, and growing environment

Research Associate

Salary:

The Research Associate is to work as part of the research and development team. Main responsibilities include target cell line development, T Cell Receptors (TCRs) and Chimeric Antigen Receptors (CARs) engineered T cells production and performing functional assays to characterize lead TCR-/CAR-T cell products. Other tasks include, but are not limited to: PCR, DNA and RNA purification, cloning, and bacterial transformation. The Research Associate will prepare technical reports and presentations to illustrate and explain experiments, data, and conclusions.

To Apply:
TCRCure Biopharma provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. TCRCure Biopharma complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

If you are interested in applying for this opportunity, please submit your resume and cover letter to lu.zhang@tcrcure.com & nc@tcrcure.com. Applications with cover letter will be reviewed first. All submissions will be evaluated, and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.

Position Requirements:
- B.S. or M.S. (M.S. preferred) in Biological Sciences or a related scientific discipline, 1-year minimum experience, industry experience preferred.
- experience in retro-/lenti-virus transduction, primary T cell culture. Primary T cell culture experience preferred
- experience in ELISA, FACS and molecular biology techniques.
- Working knowledge of molecular biology equipment and software platforms, specifically DNA construct design and sequence analysis using Vector NTI.
- Proficiency with standard software and statistical analysis is required (e.g. Microsoft Office).
- Highly organized and detail-oriented.
-team player and able to communicate experimental procedure and result clearly