Dr.Mark M. Davis is the Burt and Marion Avery Family Professor of Immunology atStanford University. Dr. Davis has been an investigator at the Howard HughesMedical Institute since 1987. He is also a member of National Academy ofSciences, American Academy of Arts and Sciences, and National Academy ofMedicine. Since his ground-breaking cloning of T cell antigen receptor (TCR) genesin 1984, Dr. Davis has been a pioneer and leader the field of molecularimmunology. Specifically, by pushing the boundaries of knowledge in multipleareas, such as antigen receptor recognition, thymic selection, and B cellterminal differentiation, his discoveries shaped our understanding of selfversus non-self discrimination, the most fundamental question in adaptiveimmunity. In addition, the Davis lab is the acclaimed source of technologyintegration and innovation. The application of protein chemistry, biophysicsand live cell imaging in Davis lab have made the study of T cell recognition themost advanced and quantitative of any system of cell-cell recognition inbiology. Technologies developed in Davis lab, such as peptide-MHC tetramers,have become standard tools in basic and clinical immunology studies. In 2004,Dr. Davis became the founding director of Stanford Institute for Immunity,Transplantation and Infection and an advocate of human immunology. He thenchanged his lab’s focus away from basic immunology to studies of the humanimmune system. Here, he has also had a tremendous impact, developing moreadvanced ways to monitor immunity and responses clinically, and integratingrepertoire sequencing, single cell genomics and proteomics technologies tochallenge immunological dogma and the power of human work to contribute tobasic immunological principals. His innovations and dedication have opened anew chapter in human immunology and translational medicine.