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The importance of TCR

T cells are mainly involved in cellular immunity. Each T cell expresses a unique receptor called T cell receptor (TCR) to recognize pathogens or tumor antigens. TCRs bind to the peptide presented by target cell’s major histocompatibility complex (MHC) to elicit downstream activation. Since the target antigen can vary, TCRs also developed vast diversity to accommodate for the broad selection of antigens. The collection of TCRs in an individual constitutes a TCR repertoire. Therefore, the diversity of TCR repertoire directly reflects the immune activation status of the individual.

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