A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Activation and amplification of tumor specific T lymphocytes driven by tumor associated antigens affect and reshape local TCR repertoire and ultimately lead to changes in TCR repertoire diversity. The diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse. Figure C shows that NSDE of mucosal TCR repertoire is the most significant marker to predict prognosis.
Fig. Diversity of the mucosal T-cell repertoire correlates with cancer outcome.
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